Pressure Stimulates Breast Cancer Cell Adhesion Independently of Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 Regulation of Focal Adhesion Kin
Pressure Stimulates Breast Cancer Cell Adhesion Independently of Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 Regulation of Focal Adhesion Kinase
Christina Downey, B.S.a, Kamal Alwan, M.D., Vijayalakshmi Thamilselvan, Ph.D.,
Liyue Zhang, Ph.D., Yan Jiang, Ph.D., Arun K. Rishi, Ph.D.,
Marc D. Basson, M.D., Ph.D..
The American Journal of Surgery 192 (2006) 631–635
Summary
Increased pressure on MDA-MB-468 breast cancer cells stimulates 25% of its adhesion. Also, overexpression o f CARP-1, which influences cancer biology, inhibits FAK phosphorylation, which parallels activation. Reduction of CARP-1, however, does not alter pressure-stimulated adhesion, which means targeting CARP-1 is unlikely to manipulate this pathway.
Significance
Breast cancer cells display pressure stimulated adhesion, which can be used for further research of regulating breast cancer cells and their positive feedback cycle. CARP-1 inhibits FAK and may contribute to modulation of some of signaling cycles, however, this should not be used to research pressure-regulated research.
5 comments:
Does this mean there is another protein that inhibits FAK in place of CARP-1?
Is CARP-1 upregulated in the presence of a pressure?
How much pressure is needed to stimulate cell adhesion?
Should the effect of pressure on the viability of cells be concerned ?
What do you mean by "this should not be used to research pressure-regulated research" what should not be used?
What positive feedback cycle of breast cancer cells is this pressure stimulated adhesion related to? How did they measure the adhesion, and what kind of pressure was used?
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