This is a really interesting article. I liked their cell-adhesion study, and I’d be curious to see how cells adhere to the implanted scaffolding with regards to altering the roughness and rigidity of the scaffold. Kim, et al. studied a possible follow-up roughness adhesion evaluation but with regards to human bone marrow stromal cells (http://www.liebertonline.com/doi/pdf/10.1089/ten.2006.0062 ). Overall, they went through a pretty good evaluation of their scaffold. I am a little confused, though, as to how they actually tested the biodegradability. Because, couldn’t the failure load be altered by increased cell-density or cell-adhesion? Well, perhaps not. Maybe it is a good test for biodegradability. I can’t think of too many other ways to test for it.
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This is a really interesting article. I liked their cell-adhesion study, and I’d be curious to see how cells adhere to the implanted scaffolding with regards to altering the roughness and rigidity of the scaffold. Kim, et al. studied a possible follow-up roughness adhesion evaluation but with regards to human bone marrow stromal cells (http://www.liebertonline.com/doi/pdf/10.1089/ten.2006.0062 ).
Overall, they went through a pretty good evaluation of their scaffold. I am a little confused, though, as to how they actually tested the biodegradability. Because, couldn’t the failure load be altered by increased cell-density or cell-adhesion? Well, perhaps not. Maybe it is a good test for biodegradability. I can’t think of too many other ways to test for it.
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