To get the ball rolling, let's take a peek at Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.
This paper is interested in how synthetic biomaterials can deliver soluble (growth factor-like) and insoluble (extracellular matrix-like) signals to cells seeded into or in the viscinity of the biomaterial. This signaling influences cell processes, and the resulting migration, proliferation, differentiation, etc. will determine cell fate and the functionality of the tissue engineered device.
This is a review paper, and thus not bad at giving you an idea of what's been done and suggesting (largely in figures 2 and 4) potential design principles. Consider how you might use this paper to inform the "future work" section of your project write-ups.
Monday, September 18, 2006
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